July 9, 2019

Erica J. Rogers
Chief Executive Officer
Silk Road Medical, Inc.
1213 Innsbruck Dr.
Sunnyvale, CA 94089

       Re: Silk Road Medical, Inc.
           Draft Registration Statement on Form S-1
           Submitted June 28, 2019
           CIK No. 0001397702

Dear Ms. Rogers:

       This is to advise you that we do not intend to review your registration

        We request that you publicly file your registration statement no later
than 48 hours prior
to the requested effective date and time. Please refer to Rules 460 and 461
regarding requests for
acceleration. We remind you that the company and its management are responsible
for the
accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
absence of action by the staff.

       Please contact Tim Buchmiller, staff attorney, at (202) 551-3635 with
any questions.


                                                            Division of
Corporation Finance
                                                            Office of
Electronics and Machinery
cc:    Philip H. Oettinger, Esq.